THE ONTOGENY OF SERUM GH BINDING PROTEIN IN MAN: A POSSIBLE INDICATOR OF HEPATIC GH RECEPTOR DEVELOPMENT

摘要: Experiments in rabbits suggest that a serum GH binding protein (GH-BP) probably is derived largely from hepatic membrane bound receptors. Human contains specific which can be easily measured by incubation with [125I] hGH and separation of hGH-BP complexes free gel filtration through an Ultrogel AcA 44 minicolumn. In each assay GH-BP activity reference (normal young adult) similarly run the results are expressed as percentage unknown divided after correction for expected inhibition resulting content serum. The mean relative (RSGH-BP) cord 11 premature infants was only 3.2 ± 1.4% (se) 17 full term 14.9 2.5%. During first two decades life there progressive rise RSGH-BP considerable individual variation. ...