Frequency-specific corticofugal modulation of the dorsal cochlear nucleus in mice
作者： Lingzhi Kong , Colin Xiong , Liang Li , Jun Yan
关键词: Modulation 、 Auditory cortex 、 Stimulation 、 Neuroplasticity 、 Anteroventral cochlear nucleus 、 Dorsal cochlear nucleus 、 Neuroscience 、 Chemistry 、 Subcortical nucleus
摘要: The primary auditory cortex (AI) modulates the sound information processing in lemniscal subcortical nuclei, including anteroventral cochlear nucleus (AVCN), a frequency-specific manner. dorsal (DCN) is non-lemniscal but it tonotopically organized like AVCN. However, remains unclear how AI DCN. This study examined impact of focal electrical stimulation on responses DCN neurons mice. We found that induced significant changes best frequency (BF) neurons. BFs were highly specific to BF differences between stimulated and recorded shifted higher when than lower BFs. showed no change similar. Moreover, shifts linearly correlated differences. Thus, our data suggest corticofugal modulation also information, similar frequency-specificity does not appear limited ascending pathway.
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