Three-dimensional tonotopic organization of the C57 mouse cochlear nucleus.

摘要: The cochlear nucleus (CN) is the first sound processing center in central auditory system that receives almost unprocessed information from periphery. functional organization of CN has been studied to a great extent many mammals, including cat, rat and bat. Yet, despite general usefulness mouse, availability various inbred strains gene-manipulated lines, our current understanding mouse remains limited. purpose this study was illustrate C57 mice, using an electrophysiological approach. Our results showed response properties neurons were similar all three subdivisions. Sound frequency systematically represented each subdivisions, i.e., anteroventral, posteroventral dorsal divisions. best decreased along dorsomedial-to-ventrolateral axis orderly progression whereas tonotopic axes relatively indistinct rostrocaudal plane. There no disruption map within subdivision CN. findings indicate cat other mammals.