Anemia, hypoxia and transfusion in patients with cervix cancer: a review.

摘要: Abstract Background and purpose : With the recent development of hemopoietic growth factors alternatives to transfusion, there has been a renewed interest in relationships between anemia, tumor hypoxia treatment outcome number human malignancies. This review is intended provoke reconsideration these issues their effect on clinical trials, aimed at improving patients with cervix cancer. Materials methods Using data from literature our own prospective series oxygenation cancer, we modeled impact anemia blood flow animal models tumors, examined relationship patients, reviewed transfusion Results Anemia may result significant reduction oxygen delivery but compensatory mechanisms reduce oxygenation. associated inferior hemoglobin levels prior during are strongly correlated size, this explain prognostic older studies. Transfusion erythropoietin ameliorate only proportion anemic patients. Critical analysis published Princess Margaret Hospital randomized trial cancer reveals that, when analyzed by intention-to-treat, did not benefit Conclusions suggests that among hypoxia, complex. Further study as an independent factor required studies alternatives, such erythropoietin, must be sufficient size detect small effects.