Genetic Characterization Indicates that a Specific Subpopulation of Pseudomonas aeruginosa Is Associated with Keratitis Infections

摘要: Pseudomonas aeruginosa is a common opportunistic bacterial pathogen that causes variety of infections in humans. Populations P. are dominated by clones can be isolated from diverse clinical and environmental sources. To determine whether specific associated with corneal infection, we used portable genotyping microarray system to analyze set 63 isolates patients ulcers (keratitis). We then population analysis compare the keratitis wider collection various nonocular identified markers subpopulation were strong disequilibrium population, including oriC, exoU, katN, unmodified flagellin, carriage genomic islands. The genome sequencing isolate (39016; representing dominant serotype O11), which was prolonged healing time, revealed several islands prophages within accessory genome. PCR amplification screening all isolates, however, provided little evidence for shared or between serotypes. twitching motility, due type IV pili, implicated virulence. demonstrated 46% O11 39016, carry distinctive pilA, encoding pilin pili. Thus, characteristics, indicating adapted cause infection.