Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
作者： Rintaro Hashizume , Noemi Andor , Yuichiro Ihara , Robin Lerner , Haiyun Gan
DOI: 10.1038/NM.3716
关键词: Biology 、 Histone demethylation 、 Histone 、 Demethylase 、 Methylation 、 Cancer research 、 Regulation of gene expression 、 Brainstem glioma 、 In vivo 、 Glioma
摘要: Pediatric brainstem gliomas often harbor oncogenic K27M mutation of histone H3.3. Here we show that GSKJ4 pharmacologic inhibition of K27 demethylase JMJD3 increases cellular …
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