EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.

作者: Louis V. LaFrance , Mark Mellinger , Celine Duquenne , Xinrong Tian , Ryan G. Kruger

DOI: 10.1038/NATURE11606

关键词:

摘要: In eukaryotes, post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the polycomb repressive …

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