作者: Dennis Mulac , Silke Lepski , Franziska Ebert , Tanja Schwerdtle , Hans-Ulrich Humpf
DOI: 10.1021/JF304569Q
关键词: HT29 Cells 、 Apoptosis 、 Cytotoxicity 、 Cytotoxic T cell 、 Biological activity 、 Alkaloid 、 Receptor 、 Stereochemistry 、 Biology 、 Biochemistry 、 Cell culture
摘要: The ergot alkaloids as secondary metabolites from fungi of the genus Claviceps are focus many investigations because their pharmacological and toxicological properties. main effects referred to an interaction with several receptor systems in human body. It is well-known that able isomerize one isomer being biologically active only weakly active, whereas activity restricted interactions. Latest have proven also show cytotoxic induce apoptosis primary cells. These seem correlate accumulation was aim our current study determine such cancer cell lines, derivatives used tumor therapy. Our results confirm apoptotic two lines (HepG2 HT-29) a high range, measurements interesting correlation between alkaloid concentrati...