Dose-response relationships for the effects of growth hormone-releasing factor-(1-44)-NH2 in young adult men and women.

摘要: Abstract Human GRF-(1–44)-NH2 (GRF–44) was administered iv in graded doses of 0.01–10 μg/kg to 35 normal young adult men and 38 women. GRF-44 stimulated the release GH i n a dose-dependent fashion, although individual responses varied widely. The ED50 values for this effect were 0.4 0.2 women midfollicular phase menstrual cycle. Maximal not significantly different, dose 1 sufficient o t produce maximal response. There was, likewise, no difference between tested midluteal phases changes PRL, LH, FSH, TSH, ACTH, β-endorphin, or cortisol at up μg/kg; 10 μg/kg, PRL increased by an average 7.6 ng/ml Side effects occurred approximately 20% both nearly all subjects given these consisted primarily flushing sense warmth. Thus, i...