Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery.

作者： Christina Bourne

DOI: 10.3390/ANTIBIOTICS3010001

关键词: Enzyme 、 Sepiapterin reductase 、 Metabolic pathway 、 Dihydrofolate reductase 、 Antimicrobial 、 Sulfonamide (medicine) 、 DHPS 、 Biology 、 Dihydropteroate 、 Biochemistry

摘要: … the ability to utilize sulfa drugs metabolically, producing … an off-target effect of sulfonamide antibiotics on a eukaryotic … The bridging phosphate groups could be replaced with other …

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