Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots.
作者： P. Andrew Karplus , Savvas N. Savvides , Tom Boone
DOI: 10.1038/75896
关键词: Common gamma chain 、 Stem cell factor 、 Janus kinase 1 、 Biochemistry 、 Platelet-derived growth factor receptor 、 Receptor tyrosine kinase 、 Biology 、 Tropomyosin receptor kinase C 、 ROR1 、 Fms-Like Tyrosine Kinase 3
摘要: Human Flt3 ligand (Flt3L) stimulates early hematopoiesis by activating a type III tyrosine kinase receptor on primitive bone marrow stem cells. The crystal structure of soluble Flt3L reveals that it is homodimer two short chain alpha-helical bundles. Comparisons structure-function relationships with the homologous hematopoietic cytokines macrophage colony stimulating factor (MCSF) and cell (SCF) suggest they have common binding mode distinct from paradigm derived complex growth hormone its receptor. Furthermore, we identify recognition features to all helical cystine-knot protein ligands activate receptors, closely related V receptors.
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