Simulation Study of a Combined Pair Production – Compton Camera for In-Vivo Dosimetry During Therapeutic Proton Irradiation

摘要: Proton and light ion beams are applied to the therapeutic irradiation of cancer patients due favorable dose deposition these particles in tissue. By means accelerated ions, a high can be accurately deposited tumor while normal tissue is spared. Since minor changes patient’s along beam path compromise success treatment, an in-vivo monitoring highly desired. Cameras detecting prompt $\gamma $ -rays emitted during therapy under investigation for this purpose. Due energy spectrum with range between few keV several MeV, it reasonable consider utilization electron-positron pair production events reconstruct origin photons. The combined use as Compton camera expected increase its efficiency. We evaluated if could suitable context by Monte-Carlo simulations. Modelling taking place prototype detector dedicated imaging were performed. analyzed efficiency system regarding events. most crucial property angular resolution. results work indicate that spatial resolution considered detection used is, principal reasons, insufficient application assessment particle therapy. Furthermore, study one order magnitude lower than setup