Amplification and expression of the c- myc oncogene in human lung cancer cell lines

作者: Cameron D. Little , Marion M. Nau , Desmond N. Carney , Adi F. Gazdar , John D. Minna

DOI: 10.1038/306194A0

关键词: CellRegulation of gene expressionGeneGene expressionCancer researchBiologyOncogeneGene duplicationDouble minuteDNA

摘要: … -fold amplification in SCLC-V lines (H60, N177, H82, N417, H446); a 4-6-fold amplification in … We wished to determine if the amplification of the c-myc gene was reflected in increased c-…

参考文章(31)
Martin D. Abeloff, Joseph C. Eggleston, Geoffrey Mendelsohn, David S. Ettinger, Stephen B. Baylin, Changes in morphologic and biochemical characteristics of small cell carcinoma of the lung The American Journal of Medicine. ,vol. 66, pp. 757- 764 ,(1979) , 10.1016/0002-9343(79)91113-6
John D. Minna, Adi F. Gazdar, Stephen B. Baylin, Edward K. Russell, Paul A. Bunn, Harvie L. Sims, Desmond N. Carney, John G. Guccion, Establishment of Continuous, Clonable Cultures of Small-Cell Carcinoma of the Lung Which Have Amine Precursor Uptake and Decarboxylation Cell Properties Cancer Research. ,vol. 40, pp. 3502- 3507 ,(1980)
Franco M. Muggia, Marcel Rozencweig, Lung cancer : progress in therapeutic research Raven Press. ,(1979)
Martin D. Abeloff, Adi F. Gazdar, Stephen B. Baylin, Gregory Goodwin, Desmond N. Carney, Activities of L-dopa decarboxylase and diamine oxidase (histaminase) in human lung cancers and decarboxylase as a marker for small (oat) cell cancer in cell culture Cancer Research. ,vol. 40, pp. 1990- 1994 ,(1980)
R Dalla-Favera, S Martinotti, R. Gallo, J Erikson, C. Croce, Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas Science. ,vol. 219, pp. 963- 967 ,(1983) , 10.1126/SCIENCE.6401867
J. Erikson, A. Ar-Rushdi, H. L. Drwinga, P. C. Nowell, C. M. Croce, Transcriptional activation of the translocated c-myc oncogene in Burkitt lymphoma Proceedings of the National Academy of Sciences of the United States of America. ,vol. 80, pp. 820- 824 ,(1983) , 10.1073/PNAS.80.3.820
B. G. Neel, S. C. Jhanwar, R. S. Chaganti, W. S. Hayward, Two human c-onc genes are located on the long arm of chromosome 8. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 79, pp. 7842- 7846 ,(1982) , 10.1073/PNAS.79.24.7842
P.J. Marangos, A.F. Gazdar, D.N. Carney, Neuron specific enolase in human small cell carcinoma cultures Cancer Letters. ,vol. 15, pp. 67- 71 ,(1982) , 10.1016/0304-3835(82)90077-5
Gregory A. Curt, Desmond N. Carney, Kenneth H. Cowan, Jacques Jolivet, Brenda D. Bailey, James C. Drake, Chien Song Kao-Shan, John D. Minna, Bruce A. Chabner, Unstable Methotrexate Resistance in Human Small-Cell Carcinoma Associated with Double Minute Chromosomes The New England Journal of Medicine. ,vol. 308, pp. 199- 202 ,(1983) , 10.1056/NEJM198301273080406
C. M. Gorman, G. T. Merlino, M. C. Willingham, I. Pastan, B. H. Howard, The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection Proceedings of the National Academy of Sciences of the United States of America. ,vol. 79, pp. 6777- 6781 ,(1982) , 10.1073/PNAS.79.22.6777