Pharmacokinetic Aspects of Inorganic Nitrate Ingestion in Man
作者： Najwa K. Cortas , Nabil W. Wakid
DOI: 10.1111/J.1600-0773.1991.TB01221.X
关键词: Urine 、 Toxicokinetics 、 Nitrite 、 Chemistry 、 Nitrate 、 Saliva 、 Chromatography 、 Ingestion 、 Oral administration 、 Blood plasma
摘要: Inorganic nitrate and nitrite concentrations were monitored simultaneously in the plasma, erythrocytes, saliva urine of five subjects following an oral dose NaNO3 (470 mumols per kg body weight). There was average 25-fold increase plasma only 10 min. after ingestion. Its concentration rose to a peak level 1.83 mM 40 min., value 49 times preload level. Erythrocyte followed similar pattern, but remained at about two thirds values. Salivary showed positive correlation with averaged 9 during 3 hr This is evidence concentration-dependent active secretion by salivary glands. The mean clearance 25.8 +/- 2.85 (S.E.M.) ml/min. corrected for area 1.73 m2 (n = 17). urinary nitrate/creatinine ratio increased 25 70 loading. These results indicate predominantly tubular excretion nitrate. Nitrite not detectable any fluids studied except saliva, where it appeared expense
sci-hub.se 参考文章(14)
I. A. Wolff, A. E. Wasserman, Nitrates, Nitrites, and Nitrosamines Science. ,vol. 177, pp. 15- 19 ,(1972) , 10.1126/SCIENCE.177.4043.15
Shigeyoshi Odashima, Overview: N-Nitroso Compounds as Carcinogens for Experimental Animals and Man Oncology. ,vol. 37, pp. 282- 286 ,(1980) , 10.1159/000225453
Michael A. Marletta, Mammalian synthesis of nitrite, nitrate, nitric oxide, and N-nitrosating agents Chemical Research in Toxicology. ,vol. 1, pp. 249- 257 ,(1988) , 10.1021/TX00005A001
H. Bartels, M. Böhmer, C. Heierli, Serum kreatininbestimmung ohne enteiweissen Clinica Chimica Acta. ,vol. 37, pp. 193- 197 ,(1972) , 10.1016/0009-8981(72)90432-9
Tannenbaum, D Fett, V. Young, P. Land, W. Bruce, Nitrite and nitrate are formed by endogenous synthesis in the human intestine Science. ,vol. 200, pp. 1487- 1489 ,(1978) , 10.1126/SCIENCE.663630
L. Green, Tannenbaum, P Goldman, Nitrate synthesis in the germfree and conventional rat Science. ,vol. 212, pp. 56- 58 ,(1981) , 10.1126/SCIENCE.6451927
LEONARD TARR, TRANSIENT METHEMOGLOBINEMIA DUE TO AMMONIUM NITRATE Archives of Internal Medicine. ,vol. 51, pp. 38- 44 ,(1933) , 10.1001/ARCHINTE.1933.00150200041004
P.M.J. Bos, P.A. Van den Brandt, M. Wedel, Th. Ockhuizen, The reproducibility of the conversion of nitrate to nitrite in human saliva after a nitrate load Food and Chemical Toxicology. ,vol. 26, pp. 93- 97 ,(1988) , 10.1016/0278-6915(88)90104-4
Jack L. Radomski, Christine Palmiri, William Lee Hearn, Concentrations of nitrate in normal human urine and the effect of nitrate ingestion Toxicology and Applied Pharmacology. ,vol. 45, pp. 63- 68 ,(1978) , 10.1016/0041-008X(78)90028-5
B. Bartholomew, M.J. Hill, The pharmacology of dietary nitrate and the origin of urinary nitrate Food and Chemical Toxicology. ,vol. 22, pp. 789- 795 ,(1984) , 10.1016/0278-6915(84)90116-9