Integrated microRNA-mRNA analysis revealing the potential roles of microRNAs in tongue squamous cell cancer

摘要: Tongue squamous cell carcinoma (TSCC) is a rare and aggressive type of cancer, which associated with poor prognosis. Identification patients at high risk TSCC tumorigenesis may provide information for the early detection metastases, potential treatment strategies. MicroRNA (miRNA; miR) mRNA expression profiling tissue samples normal control were obtained from three Gene Expression Omnibus (GEO) data series. Bioinformatics analyses, including Ontology (GO) Kyoto Encyclopedia Genes Genomes used to identify genes pathways specifically miRNA-associated oncology. A total 25 miRNAs 769 mRNAs differentially expressed in two groups assessed, all miRNA target interactions analyzed. The predominantly 38 GO terms 13 pathways. Of between groups, confirmed another GEO series, miRNA-494, miRNA-96, miRNA-183, runt-related transcription factor 1, programmed death protein 4 membrane-associated guanylate kinase most significantly altered, be central regulation TSCC. analyze large quantities microarrays through rigorous experimental planning, statistical analysis collection complete on In present study, novel differential miRNA-mRNA network was constructed, further investigation targets diagnosis