Molecular targets for cancer chemoprevention.

作者: William N William Jr , John V Heymach , Edward S Kim , Scott M Lippman , None

DOI: 10.1038/NRD2663

关键词: Cervical cancerOncologyInternal medicineFinasterideProstate cancerBreast cancerRaloxifeneTamoxifenMedicineRisk factorHepatitis B virus

摘要: Vaccines targeting infections with hepatitis B virus, a risk factor for hepatocellular cancer, and human papillomavirus, cervical are considered major clinical cancer chemoprevention successes. Molecularly targeted agents can prevent breast (raloxifene tamoxifen), colorectal adenomas (celecoxib), prostate (finasteride). Nevertheless, the broad translation of to clinic is not yet reality. Continuing research molecular targets promises expand reach personalize it as well.

参考文章(129)
M B Sporn, D L Newton, J M Smith, N M Dunlop, Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Federation proceedings. ,vol. 35, pp. 1332- 1338 ,(1976)
Christopher J. Torrance, Peta E. Jackson, Elizabeth Montgomery, Kenneth W. Kinzler, Bert Vogelstein, Allan Wissner, Maria Nunes, Philip Frost, Carolyn M. Discafani, Combinatorial chemoprevention of intestinal neoplasia. Nature Medicine. ,vol. 6, pp. 1024- 1028 ,(2000) , 10.1038/79534
Waun Ki Hong, Scott M Lippman, Cancer prevention science and practice. Cancer Research. ,vol. 62, pp. 5119- 5125 ,(2002)
Rajnish A. Gupta, Raymond N. DuBois, Combinations for cancer prevention. Nature Medicine. ,vol. 6, pp. 974- 975 ,(2000) , 10.1038/79664
Robert Benamouzig, Jacques Deyra, Antoine Martin, Bernard Girard, Eric Jullian, Benoit Piednoir, Daniel Couturier, Thierry Coste, Julian Little, Stanislas Chaussade, Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial. Gastroenterology. ,vol. 125, pp. 328- 336 ,(2003) , 10.1016/S0016-5085(03)00887-4
Gary Kelloff, Jeff Rigotty, Chinthalapally V. Rao, Bandaru S. Reddy, Kenji Tokumo, Edith Zang, Chemoprevention of Colon Carcinogenesis by Dietary Administration of Piroxicam, α-Difluoromethylornithine, 16α-Fluoro-5-androsten-17-one, and Ellagic Acid Individually and in Combination Cancer Research. ,vol. 51, pp. 4528- 4534 ,(1991)
Xiao-Chun Xu, Jae Y Ro, Jin S Lee, Dong M Shin, Waun K Hong, Reuben Lotan, None, Differential expression of nuclear retinoid receptors in normal, premalignant, and malignant head and neck tissues. Cancer Research. ,vol. 54, pp. 3580- 3587 ,(1994)
Monica M. Bertagnolli, Gary J. Kelloff, David S. Alberts, Peter T. Scardino, Wael A. Sakr, Lee W. Wattenberg, Anil K. Rustgi, Adi F. Gazdar, Michele Follen, Joyce A. O’Shaughnessy, Vassiliki A Papadimitrakopoulou, Caroline C. Sigman, Steven P. Stratton, William G. Nelson, Stephen Lam, Carol J. Fabian, Frank L. Meyskens, Michael B. Sporn, Andrew J. Dannenberg, Scott M. Lippman, Gary B. Gordon, Waun Ki Hong, Daniel D. Von Hoff, Treatment and Prevention of Intraepithelial Neoplasia: An Important Target for Accelerated New Agent Development: Recommendations of the American Association for Cancer Research Task Force on the Treatment and Prevention of Intraepithelial Neoplasia Clinical Cancer Research. ,vol. 8, pp. 314- 346 ,(2002)