Incidence, Duration, and Reappearance of Type-Specific Cervical Human Papillomavirus Infections in Young Women

摘要: Background: We describe the incidence and duration of cervical human papillomavirus (HPV) infection episodes along with risk reappearance following a period nondetection. Methods: Women (1,788) ages 16 to 23 years underwent cytologic testing PCR-based swab samples for HPV DNA (HPV-16/18/31/33/35/45/52/58/59) at ∼6-month intervals up 4 in context phase 3 clinical trial (placebo arm). type–specific rates were estimated per 100 person-years. Duration type-specific nondetection using Kaplan-Meier methods. Results: HPV-16 exhibited highest (5.9), HPV-35 HPV-33 lowest (1.0) Mean durations ranged from 13 months HPV-59 20 58 (with ongoing infections censored time treatment, if done). The within ∼3 0% 16% across types, mean 8%. Limited evidence was found role false-positive tests, missed that above threshold detection, or new acquisition accounting patterns reappearance. Conclusions: Incidence high-risk observed vary considerably more types than duration. A nontrivial proportion women nondetection, potential explanation many such events this analysis being return detectable levels previously acquired infection. Impact: has not been reported individual study finds infected exhibit reappearances. Future studies could ascertain subject-level factors potentially modify reappearance. Cancer Epidemiol Biomarkers Prev; 19(6); 1585–94. ©2010 AACR.