Cholinergic modulation of the medial prefrontal cortex: the role of nicotinic receptors in attention and regulation of neuronal activity
作者： Bernard Bloem , Rogier B. Poorthuis , Huibert D. Mansvelder
关键词: Neurophysiology 、 Neuroscience 、 Ionotropic effect 、 Prefrontal cortex 、 Acetylcholine 、 Muscarinic acetylcholine receptor 、 Acetylcholine receptor 、 Premovement neuronal activity 、 Metabotropic receptor 、 Psychology
摘要: Acetylcholine (ACh) release in the medial prefrontal cortex (mPFC) is crucial for normal cognitive performance. Despite fact that many have studied how ACh affects neuronal processing mPFC and thereby influences attention behavior, there still a lot unknown about this occurs. Here we will review evidence cholinergic modulation of plays role summarize current knowledge between receptors (AChRs) behavior receptor activation changes cortical microcircuitry. Recent implicates fast phasic cue detection attention. This focus mainly on ionotropic nicotinic less metabotropic muscarinic receptors. Finally, limitations existing studies address innovative technologies might push field forward order to gain understanding into relation ACh, activity behavior.
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