Ameliorative role of aspirin in paraquat-induced lung toxicity via mitochondrial mechanisms.

摘要: Paraquat (PQ) has accounted for numerous suicide attempts in developing countries. Aspirin (ASA) as an adjuvant treatment PQ poisoning ameliorative role. And, it's uncoupling of mitochondrial oxidative phosphorylation role been well established. The current study aimed at examining the aspirin mechanism on lung mitochondria rats exposed to PQ. Male were randomly allocated five groups: Control group, group (50 mg/kg; orally, only first day), and PQ + ASA (100, 200, 400 mg/kg; i.p.) groups 3 weeks. Mitochondrial indices respiratory chain-complex activities determined. induced interstitial fibrosis; however, ASA (400 mg/kg) led decrease this abnormal alteration. In comparison with complex II IV activity, adenosine triphosphate content had significantly increased; reactive oxygen species production, membrane permeabilization, swelling reduced. conclusion, can alleviate injury by improving dynamics.