Exploring the potential benefit of natural product extracts in paraquat toxicity

摘要: Paraquat dichloride, a herbicide used for weed and grass control, is extremely toxic to humans animals. The mechanisms of toxicity involve the redox cycling paraquat resulting in generation reactive oxygen species depletion cellular NADPH. major cause death poisoning respiratory failure due its specific uptake by oxidative insult alveolar epithelial cells inflammation with subsequent obliterating fibrosis. also causes selective degeneration dopaminergic neurons substantia nigra pars compacta, reproducing an important pathological feature Parkinson disease. Currently, there are no antidotes treatment therapeutic management mostly supportive directed towards changing disposition poison. lack effective treatments against has led exploration novel compounds antioxidant and/or anti-inflammatory properties. Recently, interest plant compounds, particularly those traditional medicine. Phytochemicals have been highlighted as possible modality variety diseases their putative efficacies safety. In this review, status extracts medicines ameliorating discussed.