Transgenic animal for production of antibodies having minimal cdrs
作者： Robert Etches , William Don Harriman , Philip A. Leighton
DOI:
关键词: Antibody 、 Pseudogene 、 Amino acid 、 Peptide sequence 、 Genetics 、 Biology 、 Transgene 、 Biochemistry 、 Immunoglobulin light chain 、 Genome 、 Gene
摘要: A transgenic animal is provided. In certain embodiments, the comprises a genome comprising: an immunoglobulin light chain locus a) functional gene comprising transcribed variable region encoding: i. CDR1, CDR2 and CDR3 regions that are composed of 2 to 5 different amino acids; ii. framework; and, operably linked gene: b) plurality pseudogene each same acids as CDRs gene; framework identical in acid sequence region.
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