Determinants of testosterone levels in human male obesity

摘要: Testosterone (T) levels are decreased in obese men, but the underlying causes incompletely understood. Our objective was to explore relation between low (free) T and male obesity, by evaluating metabolic parameters, subcutaneous adipose tissue (SAT) aromatase expression, parameters of hypothalamic–pituitary–gonadal axis. We recruited 57 morbidly men [33 had type 2 diabetes (DM2)] 25 normal-weight undergoing abdominal surgery. Fourteen also attended a follow-up, years after gastric bypass surgery (GBS). Circulating were quantified LC–MS/MS, whereas free measured using serum equilibrium dialysis sex hormone-binding globulin, luteinizing hormone, follicle-stimulating hormone immunoassay. SAT biopsies used determine adipocyte cell size expression real-time PCR. Total males versus controls, with further decrease DM2 without DM2. There no differences among study groups, steroids did not correlate expression. Pearson analysis revealed an inverse association size, triglycerides, HOMA-IR. Multivariate confirmed (β = −0.321, P 0.037 β −0.441, 0.011, respectively), independent age, HOMA-IR, or diabetes. normalized GBS. These data suggest that rather than axis is related which points size-related changes as major trigger levels.