Progressive Temporal Change in Serum SHBG, But Not in Serum Testosterone or Estradiol, Is Associated With Bone Loss and Incident Fractures in Older Men: The Concord Health and Ageing in Men Project

摘要: This study aimed to examine progressive temporal relationships between changes in major reproductive hormones across three waves of a cohort older men and (1) bone mineral density (BMD) (2) incident fractures (any, hip or non-vertebral) over an average 6 years follow-up. The CHAMP aged 70 were assessed at baseline (2005 2007, n = 1705), 2-year follow-up (n 1367), 5-year 958). Serum testosterone (T), dihydrotestosterone (DHT), estradiol (E2), estrone (E1) (by liquid chromatography-tandem mass spectrometry [LC-MS/MS]), sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating (FSH) immunoassay) measured all time-points, whereas free (cFT) was calculated using well-validated formula. Hip BMD by dual-energy X-ray absorptiometry (DXA) fracture data verified radiographically. Statistical modeling done general estimating equations (GEEs). For total BMD, univariable analyses revealed inverse associations with serum SHBG, FSH, LH positive for E1 cFT the time-points. In models adjusted multiple covariables, SHBG (β -0.029), FSH -0.065), -0.049), 0.019), 0.033) remained significantly associated BMD. However femoral neck only -0.048) -0.036) multivariable-adjusted models. Temporal change but not T, E2, other hormonal variables, any, nonvertebral incidence analyses. models, increase time any 0.060) 0.041) incidence, incidence. These indicate that circulating predicts loss risk men. Further studies are warranted further characterize as mechanism and/or biomarker health during male ageing. © 2016 American Society Bone Mineral Research.