Behavioral Effects of Deep Brain Stimulation of the Anterior Nucleus of Thalamus, Entorhinal Cortex and Fornix in a Rat Model of Alzheimer's Disease
作者： Chao Zhang , Wen-Han Hu , De-Long Wu , Kai Zhang , Jian-Guo Zhang
关键词: Entorhinal cortex 、 Medicine 、 Neuroscience 、 Fornix 、 Recognition memory 、 Morris water navigation task 、 Thalamus 、 Open field 、 Papez circuit 、 Deep brain stimulation
摘要: Background: Recent clinical and preclinical studies have suggested that deep brain stimulation (DBS) can be used as a tool to enhance cognitive functions. The aim of the present study was investigate impact DBS at three separate targets in Papez circuit, including anterior nucleus thalamus (ANT), entorhinal cortex (EC), fornix (FX), on behaviors an Alzheimer's disease (AD) rat model. Methods: Forty-eight rats were subjected intrahippocampal injection amyloid peptides 1-42 induce AD Rats divided into six groups: sham groups ANT, EC, FX. Spatial learning memory assessed by Morris water maze (MWM). Recognition investigated novel object recognition test (NORM). Locomotor anxiety-related detected open field (OF). By using two-way analysis variance (ANOVA), behavior differences between analyzed. Results: In MWM, FX performed differently terms time spent platform zone ( F (2,23) = 6.04, P 11.53, 6.29, 10.03, (1,42) 1.14, 0.29) relative center (2,42) 0.56, 0.58). Conclusions: Our results demonstrated EC facilitated hippocampus-dependent spatial more prominently than ANT DBS. addition, hippocampus-independent enhanced None showed side-effects anxiety or locomotor behaviors.
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