BDNF expression in perirhinal cortex is associated with exercise-induced improvement in object recognition memory

摘要: Abstract Physical exercise induces widespread neurobiological adaptations and improves learning memory. Most research in this field has focused on hippocampus-based spatial tasks changes brain-derived neurotrophic factor (BDNF) as a putative substrate underlying exercise-induced cognitive improvements. Chronic can also be anxiolytic causes adaptive stress-reactivity. The present study employed perirhinal cortex-dependent object recognition task well the elevated plus maze to directly test for interactions between effects of male Long Evans rats. Hippocampal cortex tissue was collected determine whether relationship BDNF performance extends non-spatial non-hippocampal-dependent task. We examined improvements persisted once regimen terminated. Our data indicate that 4 weeks voluntary every-other-day improved Importantly, expression exercising rats strongly correlated with Exercise decreased anxiety-like behavior, however there no evidence support behavior novel There trend negative hippocampal BDNF. Neither nor function levels after 2 weeks inactivity. These are first demonstrating region-specific protein memory, mediated by structures outside hippocampus consistent theory that, regard recognition, may through separable mechanisms.