Lack of effect of acid suppression therapy on gastric atrophy. Nordic Gerd Study Group.
作者： Lars Lundell , Pekka Miettinen , Helge E. Myrvold , Sven A. Pedersen , Kjell Thor
DOI: 10.1053/GAST.1999.0029900319
关键词: Helicobacter pylori 、 GERD 、 Internal medicine 、 Esophagitis 、 Atrophy 、 Basal (phylogenetics) 、 Intestinal metaplasia 、 Gastroenterology 、 Omeprazole 、 Reflux 、 Medicine
摘要: BACKGROUND & AIMS A hypothesis suggesting that profound acid inhibition therapy facilitates and hastens the development of gastric glandular atrophy in patients infected with Helicobacter pylori was investigated this randomized study comparing omeprazole antireflux surgery (ARS) for chronic gastroesophageal reflux disease (GERD). METHODS Patients esophagitis and/or GERD were enrolled; 155 to ARS long-term therapy. Baseline data obtained repeated after 3 years 131 139 omeprazole-treated patients. Histopathologic status oxyntic mucosa assessed according Sydney system. RESULTS Forty H. compared 53 group. Basal gastrin levels significantly higher pylori-infected patients, particularly No further increases serum observed during years. Despite therapy, only slight changes found prevalence inflammation corpus subjects. slow progression these irrespective no obvious difference between treatment regimens. Intestinal metaplasia (all type I) exceptionally arms. CONCLUSIONS Acid-suppressive form maintained neither nor occurrence intestinal
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