Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer (Review)
作者： Prakriti Sen , Pooja Ganguly , Niladri Ganguly
DOI: 10.3892/OL.2017.7292
关键词: Carcinogenesis 、 Histone 、 Cell cycle 、 Chromatin 、 Biology 、 DNA methylation 、 Cancer research 、 Epigenetics 、 Cancer 、 Methyltransferase 、 Genetics
摘要: Human papillomaviruses (HPVs) are double stranded circular DNA viruses that infect cutaneous and mucosal epithelial cells. Almost 99% of cervical cancer has a HPV infection. The early oncoproteins E6 E7 important in this cellular transformation process. Epigenetic mechanisms have long been known to result decisive alterations DNA, leading DNA-protein interactions, chromatin structure compaction significant gene expression. enzymes responsible for these epigenetic modifications methyl transferases (DNMTs), histone acetylases deacetylases. Epigenetics an role development by modifying the micro environment. In review, authors discuss modulating inside host cell. induce expression DNMTs which lead aberrant methylations disruption normal processes. oncoprotein may additionally directly bind transferase activity enzyme. These modulations altered levels, particularly genes involved apoptosis, cell cycle adhesion. addition, present review discusses how be targeted possible therapeutic interventions mediated cancer.
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