In-vitro bioadhesion of a buccal, miconazole slow-release tablet.
作者： STEFAN BOUCKAERT , JEAN-PAUL REMON
DOI: 10.1111/J.2042-7158.1993.TB05588.X
关键词: Bioadhesive 、 Adhesion 、 Nuclear chemistry 、 Miconazole Nitrate 、 Polymer chemistry 、 Miconazole 、 Maize starch 、 Starch 、 Chemistry 、 Modified starch 、 Polyacrylic acid
摘要: — The bioadhesive characteristics of thermally modified starch/polyacrylic acid (PAA) tablets, containing miconazole nitrate, were determined. detachment force and work adhesion significantly affected by the ratio drum-dried waxy maize starch PAA. Pure PAA showed highest while lowest observed for pure starch. There was a pronounced effect molecular weight on characteristics. Miconazole nitrate did not influence bioadhesion up to concentration 30%. additives negligible fluctuations pH strength tablet.
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