Phycotoxins in seafood--toxicological and chromatographic aspects.
作者： Bernd Luckas
DOI: 10.1016/0021-9673(92)85694-O
关键词: Marine toxin 、 Paralytic shellfish poisoning 、 Okadaic acid 、 Diarrhetic shellfish poisoning 、 Chromatography 、 Food poisoning 、 Chemistry 、 High-performance liquid chromatography 、 Derivatization 、 Saxitoxin
摘要: Two typical clinical types of algae-related seafood poisoning have attracted medical and scientific attention: paralytic shellfish (PSP) diarrhetic (DSP). Therefore, it became necessary to establish methods for the evaluation possible hazards caused by contamination with these phycotoxins. Bioassays mice or rats are common determination toxin content seafood. However, biological tests not completely satisfactory because a lack sensitivity pronounced variations. Additionally, there is growing opposition against animal testing. many efforts been undertaken determine phycotoxins chromatographic methods. PSP mainly based on high-performance liquid (HPLC) separation ion-pair chromatography followed postcolumn oxidation underivatized toxins in alkaline solution fluorescence detection. HPLC DSP okadaic acid (OA) dinophysistoxin-1 (DTX-1) characterized precolumn derivatization 9-anthryldiazomethane (ADAM) and/or 4-bromomethyl-7-methoxycoumarin (Br-Mmc), esters formed The discussed this review allow rapid, sensitive non-ambiguous individual species two most important seafood, DSP.
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