Estrogen formation in the mammalian brain: possible role of aromatase in sexual differentiation of the hippocampus and neocortex.
作者： Neil J. MacLusky , Ann S. Clark , Frederick Naftolin , Patricia S. Goldman-Rakic
DOI: 10.1016/0039-128X(87)90032-8
关键词: Mechanism (biology) 、 Aromatase 、 Sexual differentiation 、 Fetus 、 Endocrinology 、 Neocortex 、 Internal medicine 、 Hippocampus 、 Biology 、 Cerebral cortex 、 Estrogen formation
摘要: Recent studies suggest that sex differences in cognitive function may involve effects of circulating androgens on the developing cerebral cortex and hippocampus. The mechanism these is not understood. In rhesus monkeys, aromatase activity present hippocampus several areas during late fetal early postnatal life. Similarly, work rats mice indicates be capable estrogen biosynthesis development. These results are consistent with hypothesis actions local estrogen-mediated similar to those responsible for differentiation hypothalamic mechanisms controlling reproductive function.
elsevier.com
sci-hub.se 参考文章(65)
Doreen Kimura, Richard A. Harshman, Sex Differences in Brain Organization for Verbal and Non-Verbal Functions Progress in Brain Research. ,vol. 61, pp. 423- 441 ,(1984) , 10.1016/S0079-6123(08)64452-0
Robert A. Meigs, Kenneth J. Ryan, Enzymatic aromatization of steroids. I. Effects of oxygen and carbon monoxide on the intermediate steps of estrogen biosynthesis. Journal of Biological Chemistry. ,vol. 246, pp. 83- 87 ,(1971) , 10.1016/S0021-9258(18)62535-9
F. NAFTOLIN, K.J. RYAN, I.J. DAVIES, V.V. REDDY, F. FLORES, Z. PETRO, M. KUHN, R.J. WHITE, Y. TAKAOKA, L. WOLIN, The formation of estrogens by central neuroendocrine tissues Recent Progress in Hormone Research. ,vol. 31, pp. 295- 319 ,(1975) , 10.1016/B978-0-12-571131-9.50012-8
K.J. Ryan, F. Naftolin, V. Reddy, F. Flores, Z. Petro, Estrogen formation in the brain American Journal of Obstetrics and Gynecology. ,vol. 114, pp. 454- 460 ,(1972) , 10.1016/0002-9378(72)90204-9
CC Vito, MJ Baum, C Bloom, TO Fox, Androgen and estrogen receptors in perinatal ferret brain The Journal of Neuroscience. ,vol. 5, pp. 268- 274 ,(1985) , 10.1523/JNEUROSCI.05-02-00268.1985
C. Dominique Toran-Allerand, On the genesis of sexual differentiation of the general nervous system: morphogenetic consequences of steroidal exposure and possible role of alpha-fetoprotein. Progress in Brain Research. ,vol. 61, pp. 63- 98 ,(1984) , 10.1016/S0079-6123(08)64429-5
Daniel P. Kimble, Eugene Dannen, Persistent spatial maze-learning deficits in hippocampal-lesioned rats across a 7-week postoperative period Physiological Psychology. ,vol. 5, pp. 409- 413 ,(1977) , 10.3758/BF03337845
Neil J. MacLusky, Ivan Lieberburg, Bruce S. McEwen, The development of estrogen receptor systems in the rat brain: Perinatal development Brain Research. ,vol. 178, pp. 129- 142 ,(1979) , 10.1016/0006-8993(79)90093-3
R Loy, T. Milner, Sexual dimorphism in extent of axonal sprouting in rat hippocampus. Science. ,vol. 208, pp. 1282- 1284 ,(1980) , 10.1126/SCIENCE.7375941
CHARLES E. ROSELLI, WILLIAM E. ELLINWOOD, JOHN A. RESKO, Regulation of brain aromatase activity in rats. Endocrinology. ,vol. 114, pp. 192- 200 ,(1984) , 10.1210/ENDO-114-1-192