2'-Fluoro-arabinonucleic Acid (FANA): A Versatile Tool for Probing Biomolecular Interactions.

作者: Masad J Damha , Roberto El-Khoury

DOI: 10.1021/ACS.ACCOUNTS.1C00125

关键词: DNA polymeraseChemistryComputational biologyDNARNALigase activityTrans-activating crRNARNase HCas9Polymerase

摘要: … topology in telomeric G-quadruplexes. Subsequent single-molecule FRET studies elucidated the mechanism by which these parallel G-quadruplexes … that subtle structural differences …

参考文章(76)
Osman Doluca, Jamie M. Withers, Vyacheslav V. Filichev, Molecular Engineering of Guanine-Rich Sequences: Z-DNA, DNA Triplexes, and G-Quadruplexes Chemical Reviews. ,vol. 113, pp. 3044- 3083 ,(2013) , 10.1021/CR300225Q
Hala Abou Assi, Robert W. Harkness, Nerea Martin-Pintado, Christopher J. Wilds, Ramón Campos-Olivas, Anthony K. Mittermaier, Carlos González, Masad J. Damha, Stabilization of i-motif structures by 2′-β-fluorination of DNA Nucleic Acids Research. ,vol. 44, pp. 4998- 5009 ,(2016) , 10.1093/NAR/GKW402
Jory Lietard, Hala Abou Assi, Irene Gómez-Pinto, Carlos González, Mark M. Somoza, Masad J. Damha, Mapping the affinity landscape of Thrombin-binding aptamers on 2΄F-ANA/DNA chimeric G-Quadruplex microarrays. Nucleic Acids Research. ,vol. 45, pp. 1619- 1632 ,(2017) , 10.1093/NAR/GKW1357
Michael E. Østergaard, Josh Nichols, Timothy A. Dwight, Walt Lima, Michael E. Jung, Eric E. Swayze, Punit P. Seth, Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides. Molecular therapy. Nucleic acids. ,vol. 7, pp. 20- 30 ,(2017) , 10.1016/J.OMTN.2017.02.001
Hala Abou Assi, Roberto El-Khoury, Carlos González, Masad J. Damha, 2'-Fluoroarabinonucleic acid modification traps G-quadruplex and i-motif structures in human telomeric DNA. Nucleic Acids Research. ,vol. 45, pp. 11535- 11546 ,(2017) , 10.1093/NAR/GKX838
Hala Abou Assi, Yu Chen Lin, Israel Serrano, Carlos González, Masad J. Damha, Probing Synergistic Effects of DNA Methylation and 2′‐β‐Fluorination on i‐Motif Stability Chemistry: A European Journal. ,vol. 24, pp. 471- 477 ,(2018) , 10.1002/CHEM.201704591
Simon Dzatko, Michaela Krafcikova, Robert Hänsel-Hertsch, Tomas Fessl, Radovan Fiala, Tomas Loja, Daniel Krafcik, Jean-Louis Mergny, Silvie Foldynova-Trantirkova, Lukas Trantirek, Evaluation of the Stability of DNA i-Motifs in the Nuclei of Living Mammalian Cells. Angewandte Chemie. ,vol. 57, pp. 2165- 2169 ,(2018) , 10.1002/ANIE.201712284
Liande Li, Xiulong Shen, Zhongtian Liu, Michaela Norrbom, Thazha P. Prakash, Daniel O'Reilly, Vivek K. Sharma, Masad J. Damha, Jonathan K. Watts, Frank Rigo, David R. Corey, Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat. Nucleic Acid Therapeutics. ,vol. 28, pp. 23- 33 ,(2018) , 10.1089/NAT.2017.0703
Hala Abou Assi, Miguel Garavís, Carlos González, Masad J Damha, i-Motif DNA: structural features and significance to cell biology. Nucleic Acids Research. ,vol. 46, pp. 8038- 8056 ,(2018) , 10.1093/NAR/GKY735
Yajun Wang, Arlene K. Ngor, Ali Nikoomanzar, John C. Chaput, Evolution of a General RNA-Cleaving FANA Enzyme Nature Communications. ,vol. 9, pp. 5067- ,(2018) , 10.1038/S41467-018-07611-1