Development of novel electrically conductive scaffold based on hyperbranched polyester and polythiophene for tissue engineering applications.

摘要: Abstract A novel electrically conductive scaffold containing hyperbranched aliphatic polyester (HAP), polythiophene (PTh), and poly(e-caprolactone) (PCL) for regenerative medicine application was succesfully fabricated via electrospinning technique. For this purpose, the HAP (G4; fourth generation) synthesized melt polycondensation reaction from tris(methylol)propane 2,2-bis(methylol)propionic acid (bis-MPA). Afterward, functionalized with 2-thiopheneacetic in presence of N,N-dicyclohexyl carbodiimide, N-hydroxysuccinimide as coupling agent catalyst, respectively, to afford a thiophene-functionalized G4 macromonomer. This macromonomer subsequently used chemical oxidation copolymerization thiophene monomer produce star-shaped PTh core (G4-PTh). The solution G4-PTh, PCL electrospun uniform, conductive, biocompatible nanofibers. conductivity, hydrophilicity, mechanical properties these nanofibers were investigated. biocompatibility evaluated by assessing adhesion proliferation mouse osteoblast MC3T3-E1 cell line vitro degradability demonstrate their potential uses tissue engineering scaffold. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2673-2684, 2016.