Developmental roles of platelet‐derived growth factors

摘要: Summary Platelet-derived growth factor (PDGF) was originally identified in platelets and serum as a mitogen for fibroblasts, smooth muscle cells (SMC) glia culture. PDGF has since expanded to family of dimers at least four gene products, whose biological actions are mediated through two receptor tyrosine kinases, PDGFRs. The present review summarizes discusses the functions PDGFs PDGFRs developmental processes, mainly revealed genetic analysis mice. Such studies have demonstrated multiple critical roles embryonic postnatal development. seem act upon specific populations progenitor that give rise several different cell types with distinct variety processes. Analogies seen between processes controlled by PDGFs. This suggests ancestral PDGFR expression patterns may been iterated related sets morphogenetic course evolution. BioEssays 23:494‐507, 2001. fl 2001 John Wiley & Sons, Inc.