Malignant Transformation of Hymenolepis nana in a Human Host

摘要: Summary Neoplasms occur naturally in invertebrates but are not known to develop tapeworms. We observed nests of monomorphic, undifferentiated cells samples from lymph-node and lung biopsies a man infected with the human immunodeficiency virus (HIV). The morphologic features invasive behavior were characteristic cancer, their small size suggested nonhuman origin. A polymerase-chain-reaction (PCR) assay targeting eukaryotes identified Hymenolepis nana DNA. Although unrecognizable as tapeworm tissue, immunohistochemical staining probe hybridization labeled situ. Comparative deep sequencing H. structural genomic variants that compatible mutations described cancer. Invasion tissue by abnormal, proliferating, genetically altered is novel disease mechanism links infection