Endo180 and MT1-MMP are involved in the phagocytosis of collagen scaffolds by macrophages and is regulated by interferon-gamma.

摘要: Subcutaneously implanted disks of hexamethylenediisocyanate or glutaraldehyde cross-linked sheep collagen (referred to as HDSC and GDSC, respectively) in mice show large differences degradation rate. Although comparable numbers macrophages are seen phagocytosis by occurred only GDSC. The molecular mechanisms involved the essentially unknown. Immunofluorescence RT-PCR showed that Endo180 was expressed GDSC only. TissueFaxs co-localized with MT1-MMP on F4/80 positive cells, which is likely responsible for further expression correlated high levels IFN-gamma mRNA. In vitro, induced murine cultured type I (although too dampened MT1-MMP). Moreover, can be inhibited through IL-10. microenvironment between (high low IL-10 IFN- gamma HDSC) provide an explanation why summary, we first time dependent co-expression coincides phagocytosis, thus providing evidence mechanism operating foreign body reaction intracellular fibroblasts under physiological conditions.