Involvement of prolactin in the REM sleep-promoting activity of systemic vasoactive intestinal peptide (VIP).
作者： F Obal Jr , L Payne , B Kacsoh , M Opp , L Kapas
DOI: 10.1016/0006-8993(94)91647-0
关键词: Rapid eye movement sleep 、 Physiological saline 、 Secretion 、 Prolactin 、 Sleep in non-human animals 、 Period (gene) 、 Internal medicine 、 Vasoactive intestinal peptide 、 Endocrinology 、 Endogeny 、 Medicine
摘要: Abstract The involvement of pituitary prolactin (PRL) in systemic vasoactive intestinal peptide (VIP)-induced sleep was studied. Male rats were implanted with electrodes for EEG-recording, brain thermistors to record cortical temperature (Tcrt) and chronic intracardial catheters obtain blood samples deliver substances. One group (n = 8) received normal rabbit serum (NS) + physiological saline (SAL) on the baseline day injected NS VIP experimental day. In other 6), followed by administration PRL-antiserum (PRL-AS) sera or SAL 30 min before at light onset, respectively. Sleep-wake activity then recorded next 12-h period. Systemic VIP-stimulated PRL secretion as measured RIA serial obtained hour 1 postinjection. also elicited selective increases REM (REMS) pretreated NS. Tcrt not affected VIP. Administration PRL-AS blocked increase circulating levels free (non-IgG-bound) prevented VIP-enhanced REMS. Comparisons effects previously reported changes after alone indicate that has a major role mediation REMS-promoting results suggest an increased release endogenous modulates
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