Leaky gut and diabetes mellitus: what is the link?

作者: S. de Kort , D. Keszthelyi , A. A. M. Masclee

DOI: 10.1111/J.1467-789X.2010.00845.X

关键词: Immune systemType 2 diabetesDiseaseImmunologyBarrier functionAntigenIntestinal permeabilityDiabetes mellitusInsulin resistanceMedicine

摘要: … advances in the mechanistic understanding of the role of the intestinal epithelial barrier function in the development … carbohydrates, acts as an energy substrate for colonocytes and has …

参考文章(67)
Shobha S. Rao, Robert J. Church, Amer Shakil, Gastrointestinal complications of diabetes. American Family Physician. ,vol. 77, pp. 1697- 1704 ,(2008)
P J Guillausseau, J P Kevorkian, D Tielmans, M Virally-Monod, B Flourie, Y Bouhnik, A Warnet, B Porokhov, C Ajzenberg, Chronic diarrhoea and diabetes mellitus: prevalence of small intestinal bacterial overgrowth. Diabetes & Metabolism. ,vol. 24, pp. 530- 536 ,(1998)
Karvonen M, Tuomilehto J, Molchanova E, Notkola I, Taskinen O, Incidence and trends of childhood type 1 diabetes worldwide 1990-1999. Diabetic Medicine. ,vol. 23, pp. 857- 866 ,(2006)
M. Oikarinen, S. Tauriainen, T. Honkanen, S. Oikarinen, K. Vuori, K. Kaukinen, I. Rantala, M. Mäki, H. Hyöty, Detection of enteroviruses in the intestine of type 1 diabetic patients Clinical and Experimental Immunology. ,vol. 151, pp. 71- 75 ,(2008) , 10.1111/J.1365-2249.2007.03529.X
Erin B Troy, Dennis L Kasper, Beneficial effects of Bacteroides fragilis polysaccharides on the immune system Frontiers in Bioscience. ,vol. 15, pp. 25- 34 ,(2010) , 10.2741/3603
Jing-Bo Zhao, Jens Brøndum Frøkjær, Asbjørn Mohr Drewes, Niels Ejskjaer, Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus. World Journal of Gastroenterology. ,vol. 12, pp. 2846- 2857 ,(2006) , 10.3748/WJG.V12.I18.2846
C. H. Tsai, M. Hill, S. L. Asa, P. L. Brubaker, D. J. Drucker, Intestinal growth-promoting properties of glucagon-like peptide-2 in mice American Journal of Physiology-endocrinology and Metabolism. ,vol. 273, ,(1997) , 10.1152/AJPENDO.1997.273.1.E77
R. E. Ley, F. Backhed, P. Turnbaugh, C. A. Lozupone, R. D. Knight, J. I. Gordon, Obesity Alters Gut Microbial Ecology Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 11070- 11075 ,(2005) , 10.1073/PNAS.0504978102
T. Damci, I. Nuhoglu, G. Devranoglu, Z. Osar, M. Demir, H. Ilkova, Increased intestinal permeability as a cause of fluctuating postprandial blood glucose levels in Type 1 diabetic patients. European Journal of Clinical Investigation. ,vol. 33, pp. 397- 401 ,(2003) , 10.1046/J.1365-2362.2003.01161.X
F. Calcinaro, S. Dionisi, M. Marinaro, P. Candeloro, V. Bonato, S. Marzotti, R. B. Corneli, E. Ferretti, A. Gulino, F. Grasso, C. De Simone, U. Di Mario, A. Falorni, M. Boirivant, F. Dotta, Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse Diabetologia. ,vol. 48, pp. 1565- 1575 ,(2005) , 10.1007/S00125-005-1831-2