The role for gut permeability in the pathogenesis of type 1 diabetes – a solid or leaky concept?

作者: Xia Li , Mark A Atkinson

DOI: 10.1111/PEDI.12305

关键词:

摘要: … The intercellular spaces between intestinal epithelials become wide (existence of leaky gut) in T1D, due to zonulin upregulation and tight junction-related gene downregulation. The …

参考文章(63)
M. Oikarinen, S. Tauriainen, T. Honkanen, S. Oikarinen, K. Vuori, K. Kaukinen, I. Rantala, M. Mäki, H. Hyöty, Detection of enteroviruses in the intestine of type 1 diabetic patients Clinical and Experimental Immunology. ,vol. 151, pp. 71- 75 ,(2008) , 10.1111/J.1365-2249.2007.03529.X
Outi Vaarala, Is the origin of type 1 diabetes in the gut Immunology and Cell Biology. ,vol. 90, pp. 271- 276 ,(2012) , 10.1038/ICB.2011.115
Outi Vaarala, Is type 1 diabetes a disease of the gut immune system triggered by cow's milk insulin Advances in Experimental Medicine and Biology. ,vol. 569, pp. 151- 156 ,(2005) , 10.1007/1-4020-3535-7_22
Joseph G Daft, Robin G Lorenz, Role of the gastrointestinal ecosystem in the development of type 1 diabetes Pediatric Diabetes. ,vol. 16, pp. 407- 418 ,(2015) , 10.1111/PEDI.12282
S. de Kort, D. Keszthelyi, A. A. M. Masclee, Leaky gut and diabetes mellitus: what is the link? Obesity Reviews. ,vol. 12, pp. 449- 458 ,(2011) , 10.1111/J.1467-789X.2010.00845.X
Mikael Knip, Suvi M. Virtanen, Karri Seppä, Jorma Ilonen, Erkki Savilahti, Outi Vaarala, Antti Reunanen, Kari Teramo, Anu-Maaria Hämäläinen, Johanna Paronen, Hans-Michael Dosch, Timo Hakulinen, Hans K. Åkerblom, Dietary intervention in infancy and later signs of beta-cell autoimmunity. The New England Journal of Medicine. ,vol. 363, pp. 1900- 1908 ,(2010) , 10.1056/NEJMOA1004809
M. Hummel, E. Bonifacio, H. E. Naserke, A. G. Ziegler, Elimination of dietary gluten does not reduce titers of type 1 diabetes-associated autoantibodies in high-risk subjects. Diabetes Care. ,vol. 25, pp. 1111- 1116 ,(2002) , 10.2337/DIACARE.25.7.1111
Alessio Fasano, Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clinical Gastroenterology and Hepatology. ,vol. 10, pp. 1096- 1100 ,(2012) , 10.1016/J.CGH.2012.08.012
F. Horton, J. Wright, L. Smith, P. J. Hinton, M. D. Robertson, Increased intestinal permeability to oral chromium (51Cr) -EDTA in human Type 2 diabetes Diabetic Medicine. ,vol. 31, pp. 559- 563 ,(2014) , 10.1111/DME.12360
F. Calcinaro, S. Dionisi, M. Marinaro, P. Candeloro, V. Bonato, S. Marzotti, R. B. Corneli, E. Ferretti, A. Gulino, F. Grasso, C. De Simone, U. Di Mario, A. Falorni, M. Boirivant, F. Dotta, Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse Diabetologia. ,vol. 48, pp. 1565- 1575 ,(2005) , 10.1007/S00125-005-1831-2