Type I Diabetes and Celiac Disease

摘要: An 18-year-old male presents with fatigue, recent weight loss, blurred vision, intermittent diarrhea, and gastric cramping; clinical laboratory examination led to a diagnosis of type I diabetes mellitus (type DM). The etiology, presumptive risk factors, pathogenesis DM are reviewed, focus on the disease as manifestation dysregulated immune response. Major lines inquiry include preferential differentiation tolerogenic regulatory T cells in gut-associated lymphoid tissue (GALT) response metabolites gut microbiota well ligand-activated transcription factor, aryl hydrocarbon receptor (AhR), by histone deacetylase inhibitors. Additional immunomodulatory effects vitamin D ketoacidosis discussed. Diagnostic criteria, current standards care, evidence for targeted nutrient supplementation presented. Other autoimmune conditions that present celiac disease. pathogenesis, presentation, diet modification strategies this condition examined.