Influence of age and sex on basal secretion of growth hormone (GH) and on GH-induced release by porcine GH-releasing factor pGRF(1-29NH2) in growing pigs.
作者： P. Dubreuil , G. Pelletier , D. Petitclerc , H. Lapierre , Y. Couture
DOI: 10.1016/0739-7240(87)90026-9
关键词: Basal (phylogenetics) 、 Biology 、 Endogeny 、 Stimulation 、 Secretion 、 Growth hormone secretion 、 Endocrinology 、 Somatotropic cell 、 Hypothalamus 、 Somatostatin secretion 、 Internal medicine
摘要: The aim of this study was to determine the effect age and sex on basal secretory patterns growth hormone (GH) hormone-releasing factor (GRF) induced GH release. Eighteen pigs (9 castrated males 9 females) were stimulated with pGRF(1–29)NH2 at 7,11,15,19 23 weeks age. Blood samples taken from each animal via jugular vein cannulate every 20 min, 6 hr before 5 after iv GRF administration a dose 4 μg/kg. baseline levels, amplitude peaks, area under peaks overall mean serum levels decreased (P<.001) in both sexes. Age also had marked GRF-induced release: response varied considerably, depending timing episodic endogenous secretion GH. An immediate (<30 min) observed when injected end trough period or beginning peak, but there no peak period. Our results show that pGRF(1–29)NH2-induced release declines age, suggesting sensitivity somatotroph cells age; high variability stimulation depends greatly release, thus implying possible somatostatin by hypothalamus.
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