Development and validation of prognostic nomograms for metastatic gastrointestinal stromal tumour treated with imatinib
作者： Chee Khoon Lee , David Goldstein , Emma Gibbs , Heikki Joensuu , John Zalcberg
DOI: 10.1016/J.EJCA.2015.02.015
关键词: Surgery 、 Oncology 、 Imatinib 、 Nomogram 、 Internal medicine 、 GiST 、 Cancer 、 Proportional hazards model 、 Disease 、 Stromal cell 、 In patient 、 Medicine
摘要: Purpose: Metastatic gastrointestinal stromal tumour (GIST) is generally an incur- able disease with variable response to imatinib. We aimed develop prognostic nomograms predict overall survival (OS) and progression-free (PFS) for patients treated Methods: Nomograms were developed in a training cohort (n = 330) of randomised trial (EORTC-ISG-AGITG 62005 phase III study) using Cox regression models, validated 236) routine clinical care from six referral centres.
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