Polymorphisms of cancer stem cell marker gene CD133 are associated with susceptibility and prognosis of gastric cancer.
作者： Zhi-Fang Jia , Yan-Hua Wu , Dong-Hui Cao , Xue-Yuan Cao , Jing Jiang
关键词: Single-nucleotide polymorphism 、 Internal medicine 、 Odds ratio 、 Genotype 、 Hazard ratio 、 CD44 、 Genetic predisposition 、 Medicine 、 Oncology 、 Chemotherapy 、 Cancer stem cell
摘要: Aim: This study was aimed to investigate the associations between single nucleotide polymorphisms of cancer stem cell marker genes, CD44 and CD133, susceptibility prognosis gastric cancer. Patients & methods: Five in CD133 genes were genotyped 898 cases 992 controls. Results: The A/C or C/C genotypes rs2240688 associated with decreased risk comparing A/A genotype (odds ratio: 0.81; 95% CI: 0.67–0.97; p = 0.023). T allele rs3130 predicted a worse survival for patients receiving tumorectomy (hazard 1.28; 1.04–1.58; 0.020), independent from tumor node metastasis stage, vessel invasion postoperational chemotherapy. Conclusion: CD133 are promising biomarkers genetic prediction
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