CD44 but not CD24 expression is related to poor prognosis in non-cardia adenocarcinoma of the stomach

作者: Xueyuan Cao , Donghui Cao , MeiShan Jin , Zhifang Jia , Fei Kong

DOI: 10.1186/1471-230X-14-157

关键词:

摘要: Recent studies have focused on the diagnostic and prognostic significance of CD24 CD44 expression in human cancers. This study aimed to explore changes levels patients with gastric cancer assess their values. were investigated immunohistochemically tumor samples from 290 non-cardia adenocarcinoma, whom 77 had paired adjacent normal mucosa. mRNA determined by quantitative polymerase chain reaction 34 patients. Serum anti-Helicobacter pylori IgG was detected enzyme-linked immunosorbent assay. Relationships between protein parameters analyzed values evaluated Cox proportional hazards models. significantly higher compared those controls (45.5% vs. 0.0%, 61.0% P < 0.001). Among patients, overall survival rate CD44(−) CD44(+) (log-rank test, P = 0.035). However, there no significant correlation time P = 0.115). Multivariate regression analysis indicated that positive (P = 0.029), TNM staging (P < 0.001), lymphovascular invasion (P = 0.016), but not (P = 0.065), independent factors cancer. Individual associated poor carcinoma.

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