CD24 expression is associated with progression of gastric cancer.

摘要: Background/aims Mortality rates due to gastric cancer are high in Japan. To improve patient prognosis, new biomarkers for diagnosis and treatment urgently required. In this study we investigated the role of CD24, a cell adhesion glycoprotein implicated tumor proliferation, which is used as prognostic marker various cancers. Methodology We analyzed CD24 expression 173 adenocarcinomas by immunohistochemistry compared data with clinicopathological parameters overall survival. Furthermore, performed Western blotting analysis six human adenocarcinoma lines, Kato III, MKN1, MKN28, MKN45, MKN74, HGC-27. Results up-regulation was significantly correlated depth invasion (p=0.005) pathological stages (p=0.043). observed relationship between lymph node metastasis, venous lymphatic invasion. tended be higher lines derived from differentiated carcinoma, including those metastasis. Conclusions Our suggests that patients should closely monitored recurrence following resections. potential biomarker prognosis provides molecular target therapeutic strategies.