Critical Role of Tumor Microenvironment in Shaping NK Cell Functions: Implication of Hypoxic Stress

摘要: Blurring the boundary between innate and adaptive immune system, natural killer (NK) cells, a key component of immunity, are recognized as potent anticancer mediators. Extensive studies have been detailed on how NK cells get activated recognize cancer cells. In contrast, few focused tumor microenvironment-mediated immunosubversion immunoselection tumor-resistant variants may impair cell function. Accumulating evidences indicate that several subsets (macrophages, myeloid-derived suppressive T regulatory dendritic cancer-associated fibroblasts, cells), their secreted factors, well metabolic components (i.e., hypoxia) immunosuppressive roles in microenvironment able to condition become anergic. this review, we will describe react with different stromal microenvironment. This be followed by discussion role hypoxic stress regulation functions. The aim review is provide better understanding impairs functions, thereby limiting use cell-based therapy, attempt suggest more efficient tools establish favorable boost cytotoxicity control progression.