Single nucleotide polymorphisms in multiple sclerosis: disease susceptibility and treatment response biomarkers
作者： Vera Pravica , Dusan Popadic , Emina Savic , Milos Markovic , Jelena Drulovic
DOI: 10.1007/S12026-012-8273-Y
关键词: Genetics 、 Genetic marker 、 Disease 、 Single-nucleotide polymorphism 、 Environmental exposure 、 Biology 、 Multiple sclerosis 、 Pharmacogenomics 、 Bioinformatics 、 Genotype 、 Candidate gene
摘要: Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by unpredictable variable clinical course. Etiology MS involves both genetic environmental factors. New technologies identified polymorphisms associated with susceptibility among which immunologically relevant genes are significantly overrepresented. Although individual contribute only small part to susceptibility, they might be used as biomarkers, thus helping identify accurate diagnosis, predict course response therapy. This review focuses on recent progress in research genetics special emphasis possibility use single nucleotide polymorphism candidate biomarkers
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