Multiple sclerosis genetics 2010.
作者： Joseph P. McElroy , Jorge R. Oksenberg
DOI: 10.1016/J.NCL.2010.12.002
关键词:
摘要: Multiple sclerosis (MS) is a complex disease involving interactions among multiple genetic loci with modest effects and environment. The human leukocyte antigen (HLA) gene cluster in chromosome 6p21.3 represents by far the strongest MS susceptibility locus genome-wide, primary signal arising from HLA-DRB1gene class II segment of locus. Large, multicenter DNA collections have prospered as development new laboratory analytical approaches has matured at remarkable pace, allowing pursuit comprehensive "agnostic" genome-wide association studies to identify characterize non-HLA component MS. This article summarizes knowledge gained this experimental approach.
sci-hub.se 参考文章(102)
, Evidence for polygenic susceptibility to multiple sclerosis--the shape of things to come. American Journal of Human Genetics. ,vol. 86, pp. 621- 625 ,(2010) , 10.1016/J.AJHG.2010.02.027
A high-density screen for linkage in multiple sclerosis. American Journal of Human Genetics. ,vol. 77, pp. 454- 467 ,(2005) , 10.1086/444547
Orso Maria Lucherini, Luca Cantarini, Cosima Tatiana Baldari, Mauro Galeazzi, Franco Laghi Pasini, Familial clustering of recurrent pericarditis may disclose tumour necrosis factor receptor-associated periodic syndrome. Clinical and Experimental Rheumatology. ,vol. 28, pp. 405- 407 ,(2010)
Angela M. Crawley, Sylvie Faucher, Jonathan B. Angel, Soluble IL-7Rα (sCD127) Inhibits IL-7 Activity and Is Increased in HIV Infection Journal of Immunology. ,vol. 184, pp. 4679- 4687 ,(2010) , 10.4049/JIMMUNOL.0903758
Stacy J. Caillier, Farren Briggs, Bruce A. C. Cree, Sergio E. Baranzini, Marcelo Fernandez-Viña, Patricia P. Ramsay, Omar Khan, Walter Royal, Stephen L. Hauser, Lisa F. Barcellos, Jorge R. Oksenberg, Uncoupling the Roles of HLA-DRB1 and HLA-DRB5 Genes in Multiple Sclerosis Journal of Immunology. ,vol. 181, pp. 5473- 5480 ,(2008) , 10.4049/JIMMUNOL.181.8.5473
Valerie Dardalhon, Anna S Schubart, Jayagopala Reddy, Jennifer Hartt Meyers, Laurent Monney, Catherine A Sabatos, Rakesh Ahuja, Khuong Nguyen, Gordon J Freeman, Edward A Greenfield, Raymond A Sobel, Vijay K Kuchroo, None, CD226 Is Specifically Expressed on the Surface of Th1 Cells and Regulates Their Expansion and Effector Functions Journal of Immunology. ,vol. 175, pp. 1558- 1565 ,(2005) , 10.4049/JIMMUNOL.175.3.1558
, Jacob L. McCauley, Rebecca L. Zuvich, Ashley H. Beecham, Philip L. De Jager, Ioanna Konidari, Patrice L. Whitehead, Cristin Aubin, Maria Ban, Susan Pobywajlo, Rebeccah Briskin, Susan Romano, Neelum T. Aggarwal, Laura Piccio, Wendy L. McArdle, David P. Strachan, Denis Evans, Anne H. Cross, Bruce Cree, John D. Rioux, Lisa F. Barcellos, Adrian J. Ivinson, Alastair Compston, David A. Hafler, Stephen L. Hauser, Jorge R. Oksenberg, Stephen J. Sawcer, Margaret A. Pericak-Vance, Jonathan L. Haines, Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci Human Molecular Genetics. ,vol. 19, pp. 953- 962 ,(2010) , 10.1093/HMG/DDP542
S Wieczorek, S Hoffjan, A Chan, L Rey, L Harper, H Fricke, J U Holle, W L Gross, J T Epplen, P Lamprecht, Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener's granulomatosis and confirmation for multiple sclerosis in German patients Genes and Immunity. ,vol. 10, pp. 591- 595 ,(2009) , 10.1038/GENE.2009.44
Rebecca L. Zuvich, , Jacob L. McCauley, Jorge R. Oksenberg, Stephen J. Sawcer, Philip L. De Jager, Cristin Aubin, Anne H. Cross, Laura Piccio, Neelum T. Aggarwal, Denis Evans, David A. Hafler, Alastair Compston, Stephen L. Hauser, Margaret A. Pericak-Vance, Jonathan L. Haines, Genetic Variation in the IL7RA/IL7 Pathway Increases Multiple Sclerosis Susceptibility Human Genetics. ,vol. 127, pp. 525- 535 ,(2010) , 10.1007/S00439-010-0789-4
B A Johnson, J Wang, E M Taylor, S J Caillier, J Herbert, O A Khan, A H Cross, P L De Jager, P-A F Gourraud, B C A Cree, S L Hauser, J R Oksenberg, Multiple sclerosis susceptibility alleles in African Americans Genes and Immunity. ,vol. 11, pp. 343- 350 ,(2010) , 10.1038/GENE.2009.81