TNF‐α promoter polymorphisms in multiple sclerosis: no association with −308 and −238 alleles, but the −857 alleles in associated with the disease in Turkish patients

摘要: Dysregulation in the expression of pro- and anti-inflammatory cytokines is one milestones multiple sclerosis (MS) development progression. Tumour necrosis factor (TNF-alpha), a proinflammatory cytokine believed to play an important role MS pathogenesis. The objective this study investigate association between TNF-alpha promoter region (TNF-alpha-238, -308 -857) susceptibility clinical course disease. Eighty-six relapsing remitting patients 150 sex-, age- ethnic-matched controls were enrolled study. Genotyping was performed by PCR-RFLP method. We observed statistically significant increase 857 CC genotype than (P < 0.001) while CT showed negative correlation with = 0.033). No differences distribution TNF-alpha-238 alleles observed. None three polymorphisms (-238, did not show relation disease duration, Expanded Disability Status Scale or age onset. On other hand, difference TNF -857 identified low index 0.025). Although group small, results indicate that may cause Turkish population.