A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa

摘要: Background There is debate about whether the initial treatment for patients with Parkinson's disease should be levodopa or a dopamine agonist. Methods In this prospective, randomized, double-blind study, we compared safety and efficacy of D2–receptor agonist ropinirole that over period five years in 268 early disease. If symptoms were not adequately controlled by assigned study medication, could receive supplementary levodopa, administered an open-label fashion. The primary outcome measure was occurrence dyskinesia. Results Eighty-five 179 group (47 percent) 45 89 (51 completed all study. group, 29 85 (34 received no supplementation. analysis time to dyskinesia showed significant difference favor (hazard ratio remaining free dyski...