Rat arthritis due to whole group B streptococci. Clinical and histopathologic features compared with groups A and D.

摘要: Heat-killed streptococci of Groups A, B, and D injected intraperitoneally into Sprague-Dawley rats induced arthritis. The histopathologic features the arthritis were those erosive synovitis. Early acute lesions associated with deposits streptococcal antigens. serogroups physical state determined incidence, time onset, duration, severity disease, being a blend degree inflammation, tendency to relapse, occurrence ankylosis. Whole Group A usually failed induce disrupted sonication regularly after 24-hour latent period. disease lasted over 60 days caused B but only period 6-8 days. 40 ankylosed joints. With sonicated similar was induced, except that, as 24 hours. 48 2 weeks transient. In contrast its effects on cocci, abrogated capacity It is postulated that for whole streptococci, in arthritogenicity depends sensitivity cocci initial processing vivo. Processing may be partial digestion by enzymes phagocytes. Cocci such are insensitive processing, whole, tend not cause arthritis, when they do it chronic. coccus, one D, very sensitive produces transient short period, while coccus intermediate sensitivity, induces substantial severe nature remains determined.